1Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou 310015, China 2Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China 3Liangzhu Laboratory, MOE Frontier Science Center for Brain Science and Brain–Machine Integration, State Key Laboratory of Brain–Machine Intelligence, Zhejiang University, Hangzhou 311121, China 4The Institute for Brain Science and Disease, Chongqing Medical University, Chongqing 400016, China 5Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA 6Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310009, China 7State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China †These authors contributed equally to this work *Correspondence to:Ge Bai , Email:gebai@zju.edu.cn Linghui Zeng , Email:zenglh@zucc.edu.cn Xiang-Lei Yang , Email:xlyang@scripps.edu